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What is 5-MeO-DMT?

  • 5-MeO-DMT is short for 5-methoxy-N,N-dimethyltryptamine.
  • It is a naturally occurring psychedelic tryptamine found in several plants and in high concentrations in the secretion of the Bufo toad.
  • 5-MeO-DMT primarily acts as an agonist at the 5-HT1A and 5-HT2A serotonin receptors in the brain.

Therapeutic Potential

  • Anecdotal reports and early studies suggest 5-MeO-DMT could help treat anxiety and depression, but further research is needed to determine its safety and effectiveness.
  • One study found evidence that 5-MeO-DMT causes structural changes in human brain cells that may inhibit neurodegeneration.

Risks and Side Effects

  • 5-MeO-DMT can cause intense psychedelic experiences, including vivid hallucinations, altered perceptions, and a sense of spiritual insight or connection.
  • Potential side effects include anxiety, panic, increased heart rate, blood pressure, seizures, convulsions, psychosis, and hallucinations.

Legal Status

  • In the United States, 5-MeO-DMT is listed in Schedule I of the Controlled Substances Act, making it illegal to use recreationally or in therapy outside of specially approved research settings.

Metabolism and Pharmacokinetics

  • The major pathway for metabolism of 5-MeO-DMT is oxidative deamination to 5-methoxyindoleacetic acid.
  • Monoamine oxidase A (MAO-A) inhibitors like clorgyline can block the metabolism of 5-MeO-DMT, prolonging its effects.

While 5-MeO-DMT shows promise for therapeutic applications, its use carries significant risks and legal implications. Further research is needed to fully understand its potential benefits and drawbacks.

Additional information


2 grams, 5 grams, 10 grams, 1/2 ounce, 1 ounce


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